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- goat polyclonal IgG, 200 µg/ml
- epitope mapping at the N-terminus of U2AF65 of human origin
- recommended for detection of U2AF65 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine
- blocking peptide, sc-19958 P
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U2AF65 Background Information
SF3b is an U2 snRNP-associated protein complex essential for spliceosome assembly. SF3b contains the spliceosomal proteins SAPs 49, 130, 145 and 155. SAPs 130, 145 and 155 associate with one another to form a complex that is present in HeLa nuclear extracts. SAPs 49 and 145 are known to interact directly with each other. Unexpectedly, the SAP 49-SAP 145 protein-protein interaction requires the amino-terminus of SAP 49, which contains two RNA-recognition motifs. SAP 49 and SAP 145 interact directly with both U2 snRNP and the pre-mRNA, which suggests that this protein complex plays a role in tethering U2 snRNP to the branch site. U2AF recruits SAP 49 to the branch point sequence during the initial steps of spliceosome assembly. U2AF exists as a heterodimer consisting of U2AF65 and U2AF35 and is required for splicing in vivo.
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Visualizza come altri ricercatori hanno utilizzato l'anticorpo U2AF65 (N-14): sc-19958 e/o i coniugati per l'anticorpo U2AF65 (N-14).
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U2AF65 (N-14)
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U2AF65 (N-14): sc-19958. Western blot analysis of U2AF65 expression in Jurkat (A), IMR-32 (B), KNRK (C), HeLa (D) and SK-N-MC (E) nuclear extracts.
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