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- goat polyclonal IgG, 200 µg/ml
- epitope mapping within an internal region of PDE8A of human origin
- recommended for detection of PDE8A of human origin and PDE8 of mouse and rat origin by WB, IF and ELISA; also reactive with additional species, including equine, canine, bovine and porcine
- blocking peptide, sc-17231 P
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Informazioni ordini
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PDE8A Background Information
Phosphodiesterases (PDEs) are important for the downregulation of the intracellular level of the second messenger cyclic adenosine monophosphate (cAMP) by hydrolyzing cAMP to 5'AMP (1-4). Human cyclic GMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase (PDE2A) is expressed in cerebellum, neocortex, heart, kidney, placenta, lung, pulmonary artery, skeletal muscle and pancreas (5,6). PDE2A expression is detected in venous and capillary endothelial cells in cardiac and renal tissue (6). PDE8A is a high affinity cAMP-specific protein that is expressed in a wide variety of tissues including testis, ovary, small intestine, and colon (2). PDE8B is expressed specifically and abundantly in the thyroid gland and shares 65% sequence identity (83% similarity) with PDE8A (7). |
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PDE8A (R-15)
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PDE8A (R-15): sc-17231. Western blot analysis of PDE8A expression in mouse ovary extract. Note splice variants.
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