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- goat polyclonal IgG, 200 µg/ml; also available as rabbit IgG, 200 µg/ml, sc-16718-R
- epitope corresponding to a short amino acid sequence containing phosphorylated Ser 345 and Ser 346 of β2 adrenergic receptor of human origin
- recommended for detection of Ser 345 and Ser 346 phosphorylated β2 adrenergic receptor of human origin by WB, IP and IF; also reactive with additional species, including equine, canine and bovine
- blocking peptide, sc-16718 P
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Informazioni ordiniCitazioni prodotti
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| Specie |
Nome del gene |
Codice del gene |
Locus cromosoma |
Isoform (mRNA) Accession # |
codice accesso proteina |
Numero d'ordine |
| Umano |
ADRB2 |
154 |
5q33.1 |
NM_000024 |
P07550
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601665 |
| Umano |
ADRB2 |
154 |
5q33.1 |
|
P07550
|
601665 |
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β2-AR Background Information
∫2 adrenergic receptors (∫2-ARs) bind catecholamines (epinephrine and norepinephrine) and influence development, behavior, cardiac function, smooth muscle tone, and metabolism. ∫2-AR signaling complexes can contain class C L-type calcium channel CaV1.2, G protein, adenylyl cyclase, cAMP-dependent kinase and PP2A phosphatase. ∫2-ARs are present in adipose, blood, lung, brain, heart, nose, pancreas, skeletal muscle, skin and vessels. Phosphorylation of Ser 345/346 and Ser 355/356 by PKA and GRK, respectively, promotes desensitization of the ∫2-AR.
| p-β2-AR (Ser 345/Ser 346) Citazioni prodotti |
Visualizza come altri ricercatori hanno utilizzato l'anticorpo p-β2-AR (Ser 345/Ser 346): sc-16718 e/o i coniugati per l'anticorpo p-β2-AR (Ser 345/Ser 346).
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p-β2-AR (Ser 345/Ser 346)
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p-β2-AR (Ser 345/Ser 346)-R: sc-16718-R. Western blot analysis of β2-AR phosphorylation in untreated (A), PMA treated (B) and PMA and lambda protein phosphatase treated (C) HeLa whole cell lysates.
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