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- rabbit polyclonal IgG, 200 µg/ml
- epitope corresponding to amino acids 117-168 mapping within an internal region of NAT-1 of human origin
- recommended for detection of NAT-1 and NAT-2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including porcine
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Informazioni ordini
Recommended Support Products:
(click button of application of choice)
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| Specie |
Nome del gene |
Codice del gene |
Locus cromosoma |
Isoform (mRNA) Accession # |
codice accesso proteina |
Numero d'ordine |
| Umano |
NAT1 |
9 |
8p22 |
NM_000662, NM_001160170, NM_001160171, NM_001160172, NM_001160173, NM_001160174, NM_001160175, NM_001160176, NM_001160179 |
NP_000653
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108345 |
| Umano |
NAT1 |
9 |
8p22 |
NM_000662, NM_001160170, NM_001160171, NM_001160172, NM_001160173, NM_001160174, NM_001160175, NM_001160176, NM_001160179 |
P18440
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108345 |
| Umano |
NAT2 |
10 |
8p22 |
NM_000015 |
NP_000006
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243400 |
| Umano |
NAT2 |
10 |
8p22 |
NM_000015 |
P11245
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243400 |
| Mouse |
Naa15 |
17960 |
8 B3.3 |
NM_008673 |
P50294
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N/A |
| Mouse |
Nat2 |
17961 |
8 B3.3 |
NM_001168577, NM_010874 |
P50295
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N/A |
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NAT-1/2 Background Information
Arylamine N-acetyltransferases (NAT-1 and NAT-2) catalyze N- or O-acetylation of heterocyclic and arylamine substrates in the detoxification of a wide array of drugs. Certain alleles causing high levels of N-acetyltransferase activity have been associated with colon and urinary bladder cancers, as NATs also bioactivate several known carcinogens. Both NAT-1 and NAT-2 are cytoplasmic proteins and play an active role in the detoxification of many arylamine and hydrazine drugs. N-acetylation polymorphism is determined by the level of NAT activity in liver tissues, and has been linked to the action and toxicity of drugs that contain amines. Human NAT-1 is the functional homolog of rodent NAT-2, while human NAT-2 is the functional homolog of rodent NAT-1. |
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NAT-1/2 (H-52)
Clicca sull'immagine per ingrandirla
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NAT-1/2 (H-52): sc-135158. Western blot analysis of NAT-2 expression in non-transfected: sc-117752 (A) and mouse NAT-2 transfected: sc-121945 (B) 293T whole cell lysates. NAT-1/2 (H-52): sc-135158. Western blot analysis of NAT-1/2 expression in HeLa (A), A-431 (B), A549 (C) and MOLT-4 (D) whole cell lysates.
NAT-1/2 (H-52): sc-135158. Western blot analysis of NAT-2 expression in non-transfected: sc-117752 (A) and mouse NAT-2 transfected: sc-121945 (B) 293T whole cell lysates. |
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