TAF7L (S-24) Anticorpo: sc-134053

TAF7L Background Information
In eukaryotic systems, initiation of transcription from protein-coding genes is a complex process requiring RNA polymerase II and broad families of auxiliary transcription factors. One class of these factors is TFIID (transcription Factor II D), a multimeric protein complex that mediates promoter responses to various activators and repressors. TAF7L (Transcription initiation factor TFIID subunit 7-like), also known as Transcription initiation factor TFIID 50 kDa subunit and RNA polymerase II TBP-associated factor subunit Q, is a 462 amino acid testis-specific protein that is a component of TFIID. TAF7L replaces TAF7 in the spermatogenesis-specific form of TFIID, where is interacts with TAF1 and TATA-binding protein. In spermatogonia and early spermatocytes TAF7L is located within the cytoplasm, though it is localized to the nucleus in spermatocytes and round spermatids. There are three isoforms of TAF7L that are produced as a result of alternative splicing events.