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- rabbit polyclonal IgG, 100µg/ml
- epitope mapping to N-terminal and C-terminal peptides of PIP1 of human origin
- recommended for detection of PIP1 of human origin by WB, IP and ELISA
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Informazioni ordini
Recommended Support Products:
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| Specie |
Nome del gene |
Codice del gene |
Locus cromosoma |
Isoform (mRNA) Accession # |
codice accesso proteina |
Numero d'ordine |
| Umano |
PAK1IP1 |
55003 |
6p24.2 |
NM_017906 |
Q9NWT1
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607811 |
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PIP1 Background Information
PAK1-interacting protein 1 (PIP1), also known as p21-activated protein kinase-interacting protein 1 or WDR repeat-containing protein 84, is a 392 amino acid nuclear protein. PIP1 acts as a negative regulator of åPAK by binding to the N-terminal regulatory domain of åPAK. This interaction results in an inactive homodimer conformation of åPAK, which inhibits the binding of small, activating GTPases. Overexpression of PIP1 causes abnormally rounded cell morphology and reorganized actin stress fibers in embryonic fibroblasts. Containing five WD repeat domains, PIP1 is expressed in the heart, liver, lung, kidney, muscle, brain, small intestine, colon and thymus. |
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PIP1 (A-15)
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PIP1 (A-15): sc-101866. Western blot analysis of PIP1 expression in K-562 (A), SK-N-MC (B) and Hep G2 (C) nuclear extracts.
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