Calgranulin C Background Information The family of EF-hand type Ca2+-binding proteins includes calbindin (previously designated vitamin D-dependent Ca2+-binding protein), S-100å and ∫, calgranulins A (also designated MRP8), B (also designated MRP14) and C (S-100 like proteins), and the parvalbumin family members, including parvalbumin å and parvalbumin ∫ , also designated oncomodulin (OCM). Calbindin, S-100 proteins and parvalbumin proteins are each expressed in neural tissues. In addition, S-100å and ∫ are present in a variety of other tissues, and calbindin is present in intestine and kidney. Parvalbumin å is also found in fast-contracting/relaxing skeletal muscle fibers and parvalbumin ∫ is found in many tumor tissues as well as in the organ of Corti. Calbindin, S-100 proteins and parvalbulmins have all been detected in leydig cells and the testis. These proteins are thought to play a role in hormone production and spermatogenesis. Calgranulin is expressed in macrophages and epithelial cells.
