VPS18 (237.1) Anticorpo: sc-100890

VPS18 Background Information
Vacuolar sorting proteins (VPSs) are required for proper trafficking of endocytic and biosynthetic proteins to the vacuole and play an important role in the budding process of cells. VPS18 (vacuolar protein sorting 18), also known as PEP3 or hVPS18, is a 973 amino acid peripheral membrane protein that localizes to late endosomes and belongs to the VPS family. Expressed ubiquitously with highest expression in heart and lowest expression in lung, VPS18 is thought to play a role in membrane docking reactions of late endosomes and may also function in vesicle-mediated protein trafficking to lysosomal compartments. VPS18 contains one clathrin repeat and one RING-type zinc finger and exists in a large hetero-oligomeric complex with other VPS proteins, including VPS11 and VPS16. Two isoforms of VPS18 exist due to alternative splicing events.