UBE2T Background Information Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). UBE2T (Ubiquitin-conjugating enzyme E2 T), also known as PIG50 or HSPC150, is a 197 amino acid member of the E2 ubiquitin-conjugating enzyme family. Involved in the protein degradation pathway, UBE2T catalyzes the ATP-dependent attachment of ubiquitin (Ub) to target proteins, thereby tagging them for subsequent destruction by the proteasome. Additionally, UBE2T is thought to be a crucial component of the Faconi anemia pathway of DNA damage repair and, upon self-inactivation, may negatively regulate the Faconi pathway.
UBE2T (4E5)
Clicca sull'immagine per ingrandirla
UBE2T (4E5): sc-100623. Western blot analysis of UBE2T expression in HeLa whole cell lysate.
